IBN, a multifaceted communications organization engaged in connecting public companies with the investment community, today announces that Rob Etherington, President, Director and CEO of late clinical-stage biopharmaceutical company Clene Inc. (NASDAQ: CLNN), recently appeared on From Lab to Launch, a podcast sharing the inspiring stories of founders, investors, scientists, engineers and pioneers in the life sciences sector.
The podcast, hosted by Meg Sinclair, is available for on-demand listening on From Lab to Launch.
During the interview, Etherington discussed Clene’s work to address the critical unmet medical need relating to neurodegenerative diseases.
“The human nervous system is complex and highly metabolically active. To put it into context, our brain is about two to five percent of our body weight, but it is responsible for about 25 percent of our energy utilization every day. That includes about 20 percent of oxygen consumption and 20-25 percent of glucose utilization. The neurons themselves depend on the mitochondria for all of the energy required to do what we take for granted – moving, walking, talking, eating, chewing and breathing. But with neurodegenerative diseases, including ALS, these essential aspects of life start to be taken away.”
“The World Health Organization predicts that neurodegenerative diseases – amyotrophic lateral sclerosis (ALS), multiple sclerosis, Parkinson’s and others – will become the second-most prevalent cause of death in the next 20 years. So, it’s pretty obvious that a therapeutic breakthrough is urgently needed. Clene is pioneering catalytic nanotherapeutics to treat these diseases. We target improvement of mitochondrial function via the catalytic activity of our asset, CNM-Au8, to improve nicotinamide adenine dinucleotide, an essential energy metabolite, and to reduce reactive oxygen species, which are a byproduct of energy production… CNM-Au8 is pioneering a new way to restore and protect the way the neurons work.”
“Most drug development is small molecule chemistry. That’s how it was for basically 100 years. Then, in the last few decades, biologics have taken their place beside small molecule. Clene is doing neither of these. We’re intersecting physics and material science at nanoscale – small enough to cross the blood-brain barrier – to drive energy into the neurons.”
Throughout the interview, Etherington continued to discuss CNM-Au8, detailing both current and potential target applications for the nanotherapeutic, before exploring some of the challenges in developing novel therapeutics.
Learn more by listening to the full episode on From Lab to Launch.
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